J Korean Soc Neonatol.  2001 May;8(1):156-160.

A Case of Transient Hyperammonemia of the Newborn Infant

Affiliations
  • 1Department of Pediatrics, Ilsin Christian Hospital, Pusan, Korea.

Abstract

Transient hyperammonemia of the newborn is an overwhelming disease manifestated by hyperammonemic coma in ill premature infant. This recognized metabolic disorder is chiefly characterized by severe hyperammonemia in the postnatal period, a comatous state, absence of abnormal organic aciduria, normal activity of urea cycle enzymes and, usually, complete recovery. The etiology is unknown. Infant had mild respiratory distress that progressed within 48 hours to deep coma requiring ventilatory assistance and had marked hyperammonemia. The degree of neurologic impairment and developmental delay in this disorder depends on the duration of the hyperammonemic coma. So, treatment of hyperammonemia should be initiated promptly and continued vigorously. We report of a preterm infant (34+5 weeks of gestation) presenting with respiratory distress, seizure, coma, and marked elevated plasma ammonia level.

Keyword

Transient hyperammonemia; Newborn infant

MeSH Terms

Ammonia
Coma
Humans
Hyperammonemia*
Infant
Infant, Newborn*
Infant, Premature
Plasma
Seizures
Urea
Ammonia
Urea
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