Korean J Obstet Gynecol.  2012 Jan;55(1):43-46. 10.5468/KJOG.2012.55.1.43.

A case of ovarian large cell neuroendocrine carcinoma

• Lee JJ
• Lee JO
• Lee DH
• Kim MJ
• Lee DJ

• KMID: 1836763
• DOI: http://doi.org/10.5468/KJOG.2012.55.1.43

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare entity and is frequently associated with ovarian surface epithelial tumors. Since Collins et al. described the first case of mixed neuroendocrine and mucinous carcinoma, a few more cases of primary ovarian LCNECs have been reported. The prognosis of LCNECs is generally very poor even when the diagnosis is made at an early stage. A 40-year-old woman presented with a pelvic mass measuring 30 cm in diameter. She underwent an exploratory laparotomy for resection of the pelvic mass and staging if needed. After the operation, she was diagnosed of stage Ia LCNEC associated with mucinous tumor (including benign, borderline, malignant tumor) of left ovary. The patient received six cycles of paclitaxel-carboplatin chemotherapy postoperatively. There have been no signs of local tumor recurrence or metastasis at follow-up examinations during the first 8 months after the operation.

Keyword

Carcinoma; Neuroendocrine; Large cell type; Ovary

MeSH Terms

Adenocarcinoma, Mucinous
Adult
Carcinoma, Neuroendocrine
Female
Follow-Up Studies
Humans
Laparotomy
Mucins
Neoplasm Metastasis
Ovary
Prognosis
Recurrence
Mucins

Figure

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  Fig. 1 About 30 cm sized multilocular cystic lesion with enhancing portions is seen in left ovary.

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  Fig. 2 The tumor consists of large cell neuroendocrine carcinoma component (A) and mucinous adenocarcinoma component (C) (H&E, ×100). Immunohistochemically, two components are positive for CD56 (B) and CK7 (D), respectively (Immunohistochemistry, ×200).

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