J Korean Soc Coloproctol.  1998 Dec;14(4):725-734.

A Study on the Relationship between CEA Immunohistochemical Findings and Expression Rate of PCNA and Clinicopathologic Factors of Colorectal Cancers

• Hong KH
• Jeon BM
• Kim JI

Abstract

Immunohistochemical study was performed for CEA staining patterns and PCNA indices. And the relationship between immunohistochemical findings and well-known clinical prognostic factors on the purpose of the clinical usefulness was evaluated. In forty seven cases of surgically removed colorectal carcinomas, the results were as follows; CEA staining patterns were apical (17 cases) and cytoplasmic (30 cases) type. Carcinomas with cyto plasmic pattern for CEA revealed more advanced Dukes' stage and more undifferentiated type and higher incidence of lymph node metastasis and were correlated with increased serum CEA levels. But PCNA indices showed no correlation with the Dukes' stage, histologic grade and CEA staining patterns. The cytoplasmic pattern of CEA immunohistochemistry may be a useful marker suggesting more aggressive biologic behavior of the colorectal carcinomas.

Keyword

CEA (Carcinoembryonic antigen); PCNA (Proliferating cell nuclear antigen); Colorectal carcinoma

MeSH Terms

Colorectal Neoplasms*
Cytoplasm
Immunohistochemistry
Incidence
Lymph Nodes
Neoplasm Metastasis
Proliferating Cell Nuclear Antigen*
Proliferating Cell Nuclear Antigen