A comparison of Cockcroft-Gault Formula and Modification of Diet in Renal Disease Study for Estimating Glomerular Filtration Rate in Healthy Adults

Kang, Sang Yong; Park, Geun Ho; Lee, Seoung Woo; Song, Joon Ho; Lee, Sun Young; Kim, Moon Jae

Abstract

BACKGROUND: The Cockcroft-Gault (CG) and the Modification of Diet in Renal Disease study (MDRD) equations are widely used to estimate glomerular filtration rate (GFR). We performed this study to estimate the prevalence of renal dysfunction using 2 equations in a large number of healthy adults, to compare the agreement of GFR classifications by two formulae, and to know serum creatinine concentrations equivalent to renal dysfunction.
METHODS
Among the adults who underwent a health screening examination from April 2002 to March 2004, 12,276 healthy adults were selected. GFRs were calculated by CG and MDRD equations and classified as < 30, 30~59, 60~79, and >or= 80 mL/min/1.73 m2. Estimated GFR of < 60 mL/min/ 1.73 m2 was regarded as renal dysfunction.
RESULTS
The increased prevalence of renal dysfunction with age, particularly in advancing age (>60 years), was consistent across the two formulae, but the absolute magnitude of the prevalence of renal dysfunction was more prominent on CG. There was weak agreement between GFR classifications by MDRD and CG. Correlation coefficients between serum creatinine and estimated GFR were significantly higher in MDRD than in CG. Serum creatinine concentrations equivalent to 60 mL/min/1.73 m2 using average body weight and height in each age group were lower when subjects were older and female.
CONCLUSION
This study shows high prevalence of renal dysfunction after seventh decade in both sex. There is weak agreement between GFR classifications by MDRD and CG. Moreover, serum creatinine concentration equivalent to renal dysfucntion seems to be lower when subject is older and female.