Korean J Anesthesiol.  2011 Jan;60(1):3-7. 10.4097/kjae.2011.60.1.3.

Cell based therapy for the management of chronic pain

• Jeon Y

• KMID: 1827990
• DOI: http://doi.org/10.4097/kjae.2011.60.1.3

Abstract

The management of chronic pain, particularly neuropathic pain, still has significant unmet needs. In addition to inadequate symptomatic relief, there are concerns about adverse effects and addiction associated with treatments. The transplantation of cells that secrete neuroactive substances with analgesic properties into the central nervous system has only become of practical interest in more recent years, but provides a novel strategy to challenge current approaches in treating chronic pain. This review covers pre-clinical and clinical studies from both allogeneic and xenogeneic sources for management of chronic refractory pain.

Keyword

Cell therapy; Chronic pain; Encapsulated cells; Gene therapy; Genetically modified cells

MeSH Terms

Central Nervous System
Chronic Pain
Genetic Therapy
Neuralgia
Pain, Intractable
Tissue Therapy
Transplants