J Clin Neurol.
2005 Oct;1(2):174-176. 10.3988/jcn.2005.1.2.174.
Cortical Laminar Necrosis associated with Osmotic Demyelination Syndrome
- Affiliations
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- 1Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea. salee@amc.seoul.kr
- 2Department of Radiology, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 1808488
- DOI: http://doi.org/10.3988/jcn.2005.1.2.174
Abstract
- Cortical laminar necrosis has been rarely observed in osmotic demyelination syndrome. We report a 32-year-old female patient who became comatose after the rapid correction of hyponatremia. There were high signal intensities in the pons and bilateral deep gray nuclei on T2-weighted MRI images, and linear hyperintensities along the cerebral cortices on T1-weighted images with a diffuse gyriform enhancement. MR spectroscopic findings showed a decrease of the N-acetyl aspartate peak and an increase in those of the lipid and lactate complex. The case demonstrates that a severe form of osmotic demyelination syndrome accompanying cortical laminar necrosis can result from the rapid correction of hyponatremia.
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