Infect Chemother.  2005 Jun;37(3):167-170.

A Case of HIV Infection with Progressive Cerebellar Dysfunction as Initial Manifestation

Affiliations
  • 1Department of Internal Medicine, Yonsei Universitiy College of Medicine, Seoul, Korea. jmkim@yumc.yonsei.ac.kr
  • 2Department of Neurology, Yonsei Universitiy College of Medicine, Seoul, Korea.
  • 3AIDS Research Institute, Yonsei Universitiy College of Medicine, Seoul, Korea.

Abstract

Human immunodeficiency virus (HIV) is known to affect the nervous system at all levels. Neurological complications of HIV occur at all stage of HIV infection, but cerebellar degeneration associated with HIV infection in the absence of cognitive impairment is exceedingly rare. We report a case of HIV infection, in which cerebellar degeneration was the first clinical manifestation. The brain MRI showed marked isolated cerebellar atrophy with severe cerebellar degeneration, but the patient did not have cognitive dysfunction. She was diagnosed as cerebellar form of progressive multifocal leukoencephalopathy with HIV infection. HIV infection should be considered in the diagnosis of any patient with cerebellar dysfunction of unclear origin.

Keyword

AIDS; HIV; Cerebellar disease; Progressive multifocal leukoencephalopathy

MeSH Terms

Atrophy
Brain
Cerebellar Diseases*
Diagnosis
HIV Infections*
HIV*
Humans
Leukoencephalopathy, Progressive Multifocal
Magnetic Resonance Imaging
Nervous System
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