Infect Chemother.  2012 Dec;44(6):450-453. 10.3947/ic.2012.44.6.450.

A Case of Salmonella Typhi Complicating Acute Appendicitis Proven by Gene STY0312 Polymerase Chain Reaction (PCR)

• Seo MJ
• Jung YH
• Min JW
• Kim YJ
• Lee JM
• Yang H
• Kim YS
• Kim YS
• Park CM
• Yoo JH

• KMID: 1806930
• DOI: http://doi.org/10.3947/ic.2012.44.6.450

Abstract

Typhoid fever frequently manifests as gastrointestinal complications, such as ileitis or colitis, but appendicitis is quite rare. A 37-year-old man was admitted due to abdominal pain, fever and diarrhea. Two weeks before admission, he underwent an appendectomy. The blood culture upon admission revealed Salmonella Typhi. A polymerase chain reaction(PCR) was performed on the tissue of the vermiform appendix and the STY0312 gene of S. Typhi was detected. This is the first case of acute appendicitis complicated with typhoid fever proven by PCR in Korea.

Keyword

Typhoid fever; Salmonella Typhi; Acute appendicitis; Polymerase chain reaction (PCR)

MeSH Terms

Abdominal Pain
Appendectomy
Appendicitis
Appendix
Colitis
Diarrhea
Fever
Ileitis
Korea
Polymerase Chain Reaction
Salmonella
Salmonella typhi
Typhoid Fever

Figure

• 

  Figure 1 Microscopic findings of a vermiform appendix showed infiltration of numerous neutrophils in the mucosa.

• 

  Figure 2 Abdominal CT showed post-appendectomy state and thickened wall of bowel. There was no remnant of the vermiform appendix.

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  Figure 3 Gram stain from a blood culture revealed gram negative bacilli, which was finally identified as Salmonella Typhi, (A) Hematoxylin and Eosin stain, ×400 and (B) H & E stain, ×1,000.

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  Figure 4 PCR result: Lane 1: molecular marker of the 100-bp ladder; Lane 2: amplification product (384-bp band) of the gene STY0312 of S. Typhi; Lane 3: Hu18S, which indicated whether the DNA.

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