Clin Exp Reprod Med.  2011 Mar;38(1):6-9. 10.5653/cerm.2011.38.1.6.

Genetic association study of a single nucleotide polymorphism of kallikrein-related peptidase 2 with male infertility

• Lee SH
• Lee S

• KMID: 1805482
• DOI: http://doi.org/10.5653/cerm.2011.38.1.6

Abstract

OBJECTIVE
To investigate a kallikrein-related peptidase 2 (KLK2) single nucleotide polymorphism (SNP) in relation to male infertility because of its role in semen processing. We investigated the genetic association of the KLK2+255G>A genotype with male infertility.
METHODS
We genotyped the SNP site located in intron 1 (+255G>A, rs2664155) of KLK2 from 218 men with male infertility (cases) and 220 fertile males (controls). Pyrosequencing analysis was performed for the genotyping.
RESULTS
The SNP of the KLK2 gene had a statistically significant association with male infertility (p<0.05). The odds ratio for the minor allele (+255A) in the pooled sample was 0.47 (95% confidence intervals, 0.26-0.85) for rs2664155.
CONCLUSION
The relationship of KLK2 SNP to male infertility is statistically significant, especially within the non-azoospermia group. Further study is needed to understand the mechanisms associated with male infertility.

Keyword

Kallikrein-related Peptidase 2; Polymorphism, Single Nucleotide; Infertility, Male; Human

MeSH Terms

Alleles
Genetic Association Studies
Genotype
Humans
Infertility, Male
Introns
Male
Odds Ratio
Polymorphism, Single Nucleotide
Semen