Anesth Pain Med.  2007 Jan;2(1):30-36.

Effect-site Concentration of Propofol, Hemodynamic Responses and Heart Rate Variability According to Bispectral Index in Elderly Hypertensive Patients

• Baik HJ
• Kim YJ
• Kim JH

Abstract

BACKGROUND
We evaluated the changes in effect-site concentration (Ce) of propofol, hemodynamic responses and heart rate variability (HRV) in elderly patients with or without hypertension according to bispectral index (BIS) during target effect-site controlled infusion (TCEI) of propofol.
METHODS
Twenty four elderly patients with (group H, n = 12) or without hypertension (group C, n = 12) were recruited. We analyzed the spectral components of HRV at the BIS of 60-80 and 40-60 during TCEI of propofol. We also measured systolic and diastolic blood pressure (SBP and DBP), mean arterial pressure (MAP), heart rate (HR) and predicted Ce of propofol.
RESULTS
The predicted Ce in group H (2.76 +/- 0.20microg/ml) was significantly lower than that in group C (3.53 +/- 0.24microg/ml) at the BIS of 60-80. BP in both groups decreased significantly in a BIS-dependent manner. The low frequency power (LnLF) in group H decreased significantly to 83.5 +/- 4.6% and 79.1 +/- 4.4% of pre-induction value at the BIS of 60-80 and 40-60, respectively. At the BIS of 60-80, the change of HR in group H was inversely proportional to the change of total (LnTP) and high frequency power (LnHF) significantly (P < 0.05).
CONCLUSIONS
The group H required significantly lower Ce of propofol than group C for BIS 60-80. The LnLF in group H decreased significantly at the BIS of 60-80 and 40-60 compared with pre-induction value. At the BIS value of 60-80, the change of HR in group H showed inversely proportional correlation with that of LnTP and LnHF significantly.

Keyword

bispectral index; elderly patient; heart rate variability; hypertension; propofol

MeSH Terms

Aged*
Arterial Pressure
Blood Pressure
Heart Rate*
Heart*
Hemodynamics*
Humans
Hypertension
Propofol*
Propofol