Anesth Pain Med.  2010 Oct;5(4):310-313.

Effect of bronchodilator on bronchial mucus transport velocity during inhalational anesthesia

• Kim YJ
• Kim MH
• Kim HS
• Cho KR
• Lim SH
• Lee JH
• Lee KM
• Cheong SH
• Shin CM

Abstract

BACKGROUND
Volatile-based anesthesia resulted in a significantly reduced cilia beat frequency. This study was to evaluate the effect of bronchodilator on bronchial mucus transport (BMT) distance measured with a bronchoscope during Inhalational anesthesia.
METHODS
Twenty-four adult patients undergoing elective orthopedic surgery under inhalation anesthesia using sevoflurane and nitrous oxide were included. Twenty minutes after tracheal intubation, they were manually inspired without nebulization of salbutamol (control group: n = 12) or with nebulization of salbutamol(salbutamol group: n = 12). And then a single drop of 0.02 ml methylene blue was applied to the posterior mucosal surface of the right main bronchus 5 cm away from the carina under the bronchoscope. The distance of dye movement was measured 5 min after its application.
RESULTS
BMT distance and velocity of methylene blue during 5min were 6.2 +/- 3.1 mm and 1.2 +/- 0.6 mm/min in control group, and 23.3 +/- 16.6 mm and 4.7 +/- 3.3 mm/min in salbutamol group, respectively. BMT distance and velocity of methylene blue in salbutamol group were longer and faster than those in control group(P < 0.05).
CONCLUSIONS
Salbutamol facilitates the transport of bronchial secretion under sevoflurane-based inhalational anesthesia in term of BMT velocity.

Keyword

Bronchial mucus transport; Bronchodilator; Inhalational anesthesia

MeSH Terms

Adult
Albuterol
Anesthesia
Anesthesia, Inhalation
Bronchi
Bronchoscopes
Cilia
Humans
Intubation
Methyl Ethers
Methylene Blue
Mucus
Nitrous Oxide
Orthopedics
Albuterol
Methyl Ethers
Methylene Blue
Nitrous Oxide