Neonatal Med.  2014 Nov;21(4):244-250. 10.5385/nm.2014.21.4.244.

Continuous Renal Replacement Therapy in the Neonatal Intensive Care Unit: A Single-Center Study

• Oh MY
• Lee BS
• Oh SH
• Jang HJ
• Do HJ
• Kim EA
• Kim KS
• Lee JH
• Park YS
• Lee BH
• Yoo HW

• KMID: 1802884
• DOI: http://doi.org/10.5385/nm.2014.21.4.244

Abstract

PURPOSE
Continuous renal replacement therapy (CRRT) has become an essential modality for the care of critically ill pediatric patients who require renal support. However, experience with CRRT in the neonatal population is not common in Korea. In this study, we aimed to investigate the clinical features, outcomes, and complications of CRRT in neonates in a single neonatal intensive care unit (NICU).
METHODS
We reviewed the medical records of 17 neonates who underwent CRRT at a NICU of a tertiary hospital. The data included demographic characteristics, diagnosis, complications, and laboratory and CRRT parameters.
RESULTS
The median age at initiation of CRRT was 6 days after birth. All patients were treated with CRRT in continuous venovenous hemodiafiltration mode, with a median treatment duration of 57 hours. The main indication for CRRT was an inborn error of metabolism (IEM), followed by congenital renal disease and multiorgan failure. In patients with an IEM, the median plasma ammonia level at the CRRT initiation was 1,232 micromol/L, and the mean duration until the ammonia level decreased to half of the peak ammonia level was 7.3+/-2.5 hours. The overall hospital mortality rate was 41.2%. The outcomes of the 10 survivors after discharge included death (n=2), loss to follow-up (n=3), and survival with developmental delay (n=4).
CONCLUSION
Although CRRT was effective in lowering the plasma ammonia level of neonates with IEM, the associated mortality and morbidity were high. Hence, further studies are needed to optimize the CRRT protocol and to establish an effective patient referral system in Korea.

Keyword

Continuous renal replacement therapy; Neonatal intensive care unit; Inborn errors of metabolism; Hyperammonemia

MeSH Terms

Ammonia
Critical Illness
Diagnosis
Follow-Up Studies
Hemodiafiltration
Hospital Mortality
Humans
Hyperammonemia
Infant, Newborn
Intensive Care, Neonatal*
Korea
Medical Records
Metabolism
Metabolism, Inborn Errors
Mortality
Parturition
Plasma
Referral and Consultation
Renal Replacement Therapy*
Survivors
Tertiary Care Centers
Ammonia