Yonsei Med J.  2013 Nov;54(6):1305-1312. 10.3349/ymj.2013.54.6.1305.

Association between CDH13 Variants and Cardiometabolic and Vascular Phenotypes in a Korean Population

• Lee JH
• Shin DJ
• Park S
• Kang SM
• Jang Y
• Lee SH

• KMID: 1798124
• DOI: http://doi.org/10.3349/ymj.2013.54.6.1305

Abstract

PURPOSE
Although some CDH13 single nucleotide polymorphisms (SNPs) have been shown to be determinants of blood adiponectin levels, the clinical implications of CDH13 variants are not yet completely understood. The purpose of this study was to evaluate the effects of SNPs of CDH13 on metabolic and vascular phenotypes.
MATERIALS AND METHODS
We included 238 hypertensive subjects and 260 age- and sex-matched controls. Seven tagging-SNPs were identified in the CDH13 gene by whole gene sequencing. The association between these SNP variants and the risk of hypertension, metabolic traits, and carotid intima-media thickness (IMT) was examined.
RESULTS
Minor allele carriers of rs12444338 had a lower risk of hypertension, but the association turned out just marginal after adjusting confoudners. Blood glucose levels were higher in the minor allele carriers of c.1407C>T (p=0.01), whereas low-density lipoprotein-cholesterol levels were greater in those of rs6565105 (p=0.02). The minor allele of rs1048612 was associated with a higher body mass index (p=0.01). In addition, the mean carotid IMT was significantly associated with rs12444338 (p=0.02) and rs1048612 (p=0.02).
CONCLUSION
These results provide evidence that CDH13 variants are associated with metabolic traits and carotid atherosclerosis in Koreans. This study shows the multifaceted effects of CDH13 variants on cardiometabolic risk.

Keyword

CDH13 protein; human; hypertension; atherosclerosis; glucose; cholesterol

MeSH Terms

Adiponectin/genetics
Asian Continental Ancestry Group
Atherosclerosis/epidemiology/genetics
Blood Glucose/metabolism
Cadherins/*genetics
Cholesterol/blood
Female
Humans
Hypertension/epidemiology/genetics
Male
Middle Aged
Polymorphism, Single Nucleotide/genetics
Adiponectin
Blood Glucose
Cadherins
Cholesterol

Figure

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  Fig. 1 Bar graph showing carotid IMT in each genotype of rs12444338 and rs1048612. IMT, intima-media thickness.

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