J Korean Med Sci.  2009 Feb;24(1):158-161. 10.3346/jkms.2009.24.1.158.

A Case of Graves' Disease Combined with Hantaan Virus Infection

• Jin HY
• Kang SM
• Kim SY
• Park JH
• Baek HS
• Park TS

• KMID: 1794424
• DOI: http://doi.org/10.3346/jkms.2009.24.1.158

Abstract

Graves' disease (GD) is generally presented by thyrotoxicosis with hyperthyroidism, and it is an organ-specific autoimmune disease induced by thyroid-stimulating hormone receptor autoantibodies. However, among diverse etiologies, viral infections have been suggested to trigger or to be involved in the pathogenesis of GD. Hantaan virus infection causing hemorrhagic fever with renal syndrome (HFRS) is common in South Korea and its pathogenesis is suggested to be an immunologic mechanism. We have experienced a patient who was diagnosed as HFRS with thyrotoxicosis. So we herein report the case as GD combined with the hantaan virus infection.

Keyword

Graves' Disease; Hemorrhagic Fever with Renal Syndrome; Hantaan Virus

MeSH Terms

Graves Disease/complications/*diagnosis/ultrasonography
*Hantaan virus
Hemorrhagic Fever with Renal Syndrome/complications/*diagnosis
Humans
Male
Radiopharmaceuticals/diagnostic use
Thyrotoxicosis/diagnosis
Young Adult

Figure

• 

  Fig. 1 Thyroid ultrasonography using 7.5 MHz probe and 99m-Tc (technecium) thyroid scan of the patient. (A) The anteroposterior diameter of the isthmus was increased to 6 mm. (B) The right lobe showed heterogenic echogenecity with increased vascularity and enlarged size. (C) The left lobe showed thyroid inferno and both lobes showed the same findings. (D) Both lobes showed increased trapping without a nodular region.

• 

  Fig. 2 Vital signs during hospitalization. (A) Body temperature change. (B) Systolic (Sys) and diastolic (Dia) blood pressure (BP) and heart rate (HR) changes. (C) Urine output change.

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