J Korean Med Sci.  2013 Aug;28(8):1194-1199. 10.3346/jkms.2013.28.8.1194.

Incidence, Etiology, and Outcomes of Rhabdomyolysis in a Single Tertiary Referral Center

• Park JS
• Seo MS
• Gil HW
• Yang JO
• Lee EY
• Hong SY

• KMID: 1793025
• DOI: http://doi.org/10.3346/jkms.2013.28.8.1194

Abstract

We have encountered numerous cases of rhabdomyolysis associated with acute pesticide intoxication; however, the cause, incidence, and treatment outcomes of rhabdomyolysis have not been studied. The current study involved 2,125 patients hospitalized with acute chemical poisoning. Based on clinical and laboratory parameters and treatment outcomes, we found that overall incidence of rhabdomyolysis in our hospital was 0.06% (93 of 143,830 patients admitted), but the incidence associated with acute pesticide intoxication was 1.8% (33 of 1,793 cases). The incidence of rhabdomyolysis after pesticide intoxication was significantly higher in men than in women (P = 0.010). The amount of pesticide ingested was significantly higher in rhabdomyolysis patients than that in those who did not develop rhabdomyolysis (mean +/- SD, 114.1 +/- 79.5 mL vs 74.1 +/- 94.2 mL, P = 0.010). Our results show that pesticide intoxication is a frequent cause of rhabdomyolysis and is more common among men than women. The volume of pesticide ingested, and not the degree of human toxicity, is the main factor influencing the incidence of rhabdomyolysis.

Keyword

Acute Kidney Injury; Intoxication; Pesticides; Rhabdomyolysis; Surfactant

MeSH Terms

Adult
Age Factors
Aged
Alcohol Drinking
Female
Hospitalization
Humans
Incidence
Length of Stay
Male
Middle Aged
Pesticides/poisoning
Rhabdomyolysis/*epidemiology/etiology
Sex Factors
Tertiary Care Centers
Treatment Outcome
Pesticides

Figure

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  Fig. 1 Causes of rhabdomyolysis in the current study. The numbers of cases are shown in parentheses. CNS, central nervous system.

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