Korean J Gastroenterol.  2011 May;57(5):319-322. 10.4166/kjg.2011.57.5.319.

A Case of Primary Mucoepidermoid Carcinoma Arising from the Common Bile Duct

• Song BJ
• Kwon JH
• Kim JJ
• Lee JW
• Min SY
• Lee KB
• Jang JY
• Ryu JK

• KMID: 1792790
• DOI: http://doi.org/10.4166/kjg.2011.57.5.319

Abstract

Mucoepidermoid carcinoma of the bile duct is an extremely rare tumor. Seventeen cases originating from intrahepatic bile duct and 2 cases from common hepatic duct have been reported in the English literature. Mucoepidermoid carcinoma arising from the common bile duct has not been previously reported. A 68 year-old man was admitted due to obstructive jaundice. Computed tomography showed a malignant tumor of the common bile duct located in the intrapancreatic segment. Filling defects of the distal common bile duct was seen on endoscopic retrograde cholangiogram. Under the impression of bile duct cancer, pylorus-preserving pancreatoduodenectomy was performed. Histologic diagnosis of the resected specimen was mucoepidermoid carcinoma of the common bile duct. After surgery, the patient received concurrent chemoradiotherapy, and planned to receive additional chemotherapy. We herein report on a first case of primary mucoepidermoid carcinoma of the common bile duct, and review the literature.

Keyword

Carcinoma, Mucoepidermoid; Common bile duct

MeSH Terms

Aged
Antimetabolites, Antineoplastic/therapeutic use
Carcinoma, Mucoepidermoid/*diagnosis/surgery/therapy
Cholangiopancreatography, Endoscopic Retrograde
Combined Modality Therapy
Common Bile Duct Neoplasms/*diagnosis/surgery/therapy
Fluorouracil/therapeutic use
Humans
Male
Pancreaticoduodenectomy
Tomography, X-Ray Computed

Figure

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  Fig. 1. Abdominal CT findings. An intraluminal mass and bile duct dilatation were seen in the distal common bile duct.

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  Fig. 2. Endoscopic retrograde cholangiographic findings. A filling defect was seen at the level of the distal common bile duct with bile duct the dilatation, and plastic stent was inserted.

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  Fig. 3. Magnetic resonance cholangiopancreatographic findings. Diffuse dilatation of bile ducts was seen with filling defect at the distal common bile duct.

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  Fig. 4. Resected specimen. Gross specimen showed polypoid mass at distal common bile duct.

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  Fig. 5. Microscopic findings. (A) High power field view showed both squamous carcinomas (left side) and mucin producing carcinomas (right side) (H&E stain, ×400). (B) Nuclear staining of p16 protein in squamous carcinomas (immunohistochemistry, ×400).

Reference

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