Korean J Gastroenterol.  2011 May;57(5):281-287. 10.4166/kjg.2011.57.5.281.

Clinical Characteristics of Gastroesophageal Reflux Disease with Esophageal Injury in Korean: Focusing on Risk Factors

• Lee SJ
• Jung MK
• Kim SK
• Jang BI
• Lee SH
• Kim KO
• Kim ES
• Cho KB
• Park KS
• Kim EY
• Jung JT
• Kwon JG
• Lee JH
• Yang CH
• Park CK
• Seo HE
• Jeon SW

• KMID: 1792784
• DOI: http://doi.org/10.4166/kjg.2011.57.5.281

Abstract

BACKGROUND/AIMS
Recent studies suggest that the prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea. However, studies on risk factors for GERD have yielded inconsistent results. The aims of this study were to compare clinical features between symptomatic syndromes without esophageal injury (=non-erosive disease [NED]) and syndromes with esophageal injury (=erosive disease [ED]), and to determine risk factors associated ED.
METHODS
A total of 450 subjects who visited gastroenterology clinics of six training hospitals in Daegu from March 2008 to April 2010 were consecutively enrolled. The subjects were asked to complete a questionnaire which inquired about gastroesophageal reflux symptoms. The questionnaire also included questions about smoking, alcohol drinking, consumption of coffee, use of drugs, exercise, and other medical history. The subjects were subdivided into NED and ED groups.
RESULTS
The proportion of subjects in each NED and ED group was 172 (38.2%) and 278 (61.8%). Male gender, smoking, alcohol drinking, consumption of coffee, large waist circumference, infrequent medication of antacids, aspirin and NSAIDs, infrequent and mild GERD symptoms were all significantly associated with ED on univariate analysis. Age, hiatal hernia, diabetes mellitus, body mass index, change in weight during 1 year, and number of typical GERD symptoms were not independent risk factors for ED. However, the association between ED and alcohol drinking, infrequent medication of antacids, mild typical GERD symptoms remained as strong risk factors after adjustments on multivariate logistic analysis.
CONCLUSIONS
Independent risk factors associated with ED were alcohol drinking, infrequent medication of antacids and mild typical GERD symptoms.

Keyword

Gastroesophageal reflux; Endoscopy; Alcohol drinking; Antacids; Signs and symptoms

MeSH Terms

Adolescent
Adult
Aged
Alcohol Drinking
Antacids/therapeutic use
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
Aspirin/therapeutic use
Barrett Esophagus/complications/diagnosis
Body Mass Index
Coffee
Endoscopy, Gastrointestinal
Esophagitis, Peptic/complications/*diagnosis
Female
Gastroesophageal Reflux/complications/*diagnosis
Humans
Logistic Models
Male
Middle Aged
Questionnaires
Republic of Korea
Risk Factors
Severity of Illness Index
Sex Factors
Waist Circumference

Reference

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