Korean J Intern Med.
2014 May;29(3):383-387. 10.3904/kjim.2014.29.3.383.
Distant subcutaneous recurrence of a parathyroid carcinoma: abnormal uptakes in the 99mTc-sestamibi scan and 18F-FDG PET/CT imaging
- Affiliations
-
- 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. injkim@pusan.ac.kr
- 2Department of Nuclear Medicine, Pusan National University School of Medicine, Busan, Korea.
- KMID: 1792066
- DOI: http://doi.org/10.3904/kjim.2014.29.3.383
Abstract
- We report a rare case of distant subcutaneous parathyroid carcinoma recurrence. A 50-year-old woman was referred to our hospital because of sustained hypercalcemia despite surgical removal of a parathyroid carcinoma. A focal uptake in the upper mediastinal area was detected in a 99mTc-sestamibi scan, and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) imaging demonstrated a subcutaneous mass. She underwent tumor resection, and the pathological findings were consistent with a parathyroid carcinoma. The postoperative serum parathyroid hormone (PTH) level remained within normal limits. However, a new palpable solitary mass was identified in the upper portion of the left breast 1 year postoperatively. Both a 99mTc-sestamibi scan and 18F-FDG PET/CT imaging revealed an abnormal lesion in the upper breast, and subsequent pathology reports confirmed parathyroid carcinoma metastasis. Serum PTH and calcium levels fell within normal ranges after tumor resection. Two subcutaneous recurrent lesions appeared likely due to tumor seeding during the previous endoscopic operation at a local hospital.
Keyword
MeSH Terms
-
Biological Markers/blood
Breast Neoplasms/blood/radiography/*radionuclide imaging/*secondary/surgery
Carcinoma/blood/radiography/*radionuclide imaging/*secondary/surgery
Female
Fluorodeoxyglucose F18/*diagnostic use
Humans
Middle Aged
Multimodal Imaging
Parathyroid Hormone/blood
Parathyroid Neoplasms/blood/*pathology/surgery
*Positron-Emission Tomography
Predictive Value of Tests
Radiopharmaceuticals/*diagnostic use
Technetium Tc 99m Sestamibi/*diagnostic use
Time Factors
*Tomography, X-Ray Computed
Treatment Outcome
Biological Markers
Fluorodeoxyglucose F18
Parathyroid Hormone
Radiopharmaceuticals
Technetium Tc 99m Sestamibi
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