Ann Lab Med.  2014 Mar;34(2):166-169. 10.3343/alm.2014.34.2.166.

Acute Lymphoblastic Leukemia with Mature B-Cell Phenotype and t(9;11;11)(p22;q23;p11.2): A Case Study and Literature Review

• Kim B
• Lee ST
• Kim HJ
• Lee SH
• Yoo KH
• Koo HH
• Kim SH

• KMID: 1791914
• DOI: http://doi.org/10.3343/alm.2014.34.2.166

Abstract

No abstract available.

MeSH Terms

Aged
B-Lymphocytes/*cytology/metabolism
Child
*Chromosomes, Human, Pair 11
*Chromosomes, Human, Pair 9
Female
Humans
Immunophenotyping
Infant
Karyotyping
Male
Myeloid-Lymphoid Leukemia Protein/genetics/metabolism
Oncogene Proteins, Fusion/genetics/metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis
Translocation, Genetic
Oncogene Proteins, Fusion
Myeloid-Lymphoid Leukemia Protein

Figure

• 

  Fig. 1 (A) Blasts of the patient exhibit non-FAB-L3 morphology. (B) Scatter plots of flow cytometric immunophenotyping show blasts with CD19+, CD10+, CD34-, terminal deoxynucleotidyl transferase (TdT)-, and surface immunoglobulin (sIg) λ+.Abbreviation: FAB, French-American-British classification.

• 

  Fig. 2 (A) Conventional karyotyping indicates the karyotype of t(9;11;11)(p22;q23;p11.2). The arrows indicate chromosomes showing abnormalities. (B) FISH analysis indicates the MLL break-apart signals. LSI MLL(B-A) probe refers to the locus specific identifier MLL break apart probe. (C) Molecular analysis by reverse transcription (RT)-PCR showing a 367-bp amplicon corresponding to the MLL ex8-MLLT3 (AF9) ex9 fusion transcript. M represents the lane for the amplicon size marker, and pt for the patient described.

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