Ann Lab Med.  2014 Mar;34(2):98-103. 10.3343/alm.2014.34.2.98.

Mean Platelet Volume and Vitamin D Level

• Cumhur Cure M
• Cure E
• Yuce S
• Yazici T
• Karakoyun
• Efe H

• KMID: 1791901
• DOI: http://doi.org/10.3343/alm.2014.34.2.98

Abstract

BACKGROUND
Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV.
METHODS
This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively.
RESULTS
The vitamin D level in Group 1 (7.7+/-1.9 ng/mL) was lower than that in Group 2 (15.1+/-1.6 ng/mL, P<0.001) and Group 3 (25.6+/-6.3 ng/mL, P<0.001). The MPV in Group 3 (7.5+/-1.0 fL) was lower than that in Group 1 (8.1+/-1.1 fL, P<0.001) and Group 2 (7.9+/-1.0 fL, P=0.009). Linear regression analysis showed that low levels of vitamin D (beta=-0.109, P=0.019) was independently associated with increased MPV.
CONCLUSIONS
There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.

Keyword

Vitamin D; Deficiency; Mean platelet volume; Cardiovascular diseases

MeSH Terms

Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Blood Glucose/analysis
Blood Platelets/*cytology
Cell Size
Female
Humans
Immunoassay
Luminescent Measurements
Male
Middle Aged
Vitamin D/*analysis
Vitamin D Deficiency/metabolism/pathology
Young Adult
Blood Glucose
Vitamin D

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