Korean J Gastroenterol.  2014 Apr;63(4):209-215. 10.4166/kjg.2014.63.4.209.

Prognostic Factors for Metastatic Colorectal Cancer after First-line Chemotherapy with FOLFOX-4 or FOLFIRI Regimen

• Kim JH
• Choi PR
• Park SJ
• Park MI
• Moon W
• Kim SE
• Lee GW

• KMID: 1791877
• DOI: http://doi.org/10.4166/kjg.2014.63.4.209

Abstract

BACKGROUND/AIMS
Information on prognostic factors for metastatic colorectal cancer is an important basis for planning the treatment and predicting the outcomes of the patients; however, it has not been well established. The aim of this study was to identify factors that predict results of chemotherapy and to establish a plan for treatment of patients whose tumors are inoperable due to metastatic colorectal cancer.
METHODS
We conducted a retrospective review of records from 75 patients treated for colorectal cancer in Kosin University Gospel Hospital, from October 2004 to September 2008. Patients with inoperable tumors due to metastasis at the time of diagnosis who were treated with oxaliplatin or irinotecan as the first-line treatment were included in this study. We investigated the factors that might have an effect on overall survival.
RESULTS
A total of 75 patients were included in this study. Results of univariate analysis showed that hemoglobin (Hb) > or =10 g/dL at the time of diagnosis, no increase in CEA on the follow-up examination after chemotherapy, chemotherapy plus surgery, and better response to chemotherapy were significant prognostic factors. Results of multivariate analysis showed that Hb > or =10 g/dL at the time of diagnosis (p<0.001), surgery after chemotherapy (p=0.001), and better response to chemotherapy (p=0.014) were significant prognostic factors.
CONCLUSIONS
In this study, Hb > or =10 g/dL at the time of diagnosis, surgery after chemotherapy, and better response to chemotherapy were significant prognostic factors for metastatic colorectal cancer.

Keyword

Colorectal neoplasms; Prognostic factors; Chemotherapy

MeSH Terms

Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Camptothecin/*analogs & derivatives/therapeutic use
Colorectal Neoplasms/*diagnosis/*drug therapy/mortality/surgery
Female
Fluorouracil/administration & dosage/therapeutic use
Hemoglobins/analysis
Humans
Kaplan-Meier Estimate
Leucovorin/administration & dosage/therapeutic use
Male
Middle Aged
Neoplasm Metastasis
Odds Ratio
Organoplatinum Compounds/therapeutic use
Prognosis
Retrospective Studies
Camptothecin
Fluorouracil
Hemoglobins
Leucovorin
Organoplatinum Compounds

Figure

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  Fig. 1. Overall survival according to whether or not surgery was performed after initial chemotherapy.

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  Fig. 2. Overall survival according to initial hemoglobin (Hb) level.

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  Fig. 3. Overall survival according to whether or not follow-up CEA level was elevated.

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  Fig. 4. Overall survival according to disease response.

Reference

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