Ann Pediatr Endocrinol Metab.  2015 Mar;20(1):8-12. 10.6065/apem.2015.20.1.8.

Pubertal growth and epiphyseal fusion

• Shim KS

• KMID: 1789525
• DOI: http://doi.org/10.6065/apem.2015.20.1.8

Abstract

The complex networks of nutritional, cellular, paracrine, and endocrine factors are closely related with pubertal growth and epiphyseal fusion. Important influencing factors include chondrocyte differentiation capacity, multiple molecular pathways active in the growth plate, and growth hormone-insulin-like growth factor-I axis activation and epiphyseal fusion through estrogen and its receptors. However, the exact mechanisms of these phenomena are still unclear. A better understanding of the detailed processes involved in the pubertal growth spurt and growth plate closure in longitudinal bone growth will help us develop methods to efficiently promote pubertal growth and delay epiphyseal fusion with fewer adverse effects.

Keyword

Growth; Puberty; Growth plate

MeSH Terms

Adolescent
Axis
Bone Development
Chondrocytes
Estrogens
Growth Plate
Humans
Puberty
Estrogens

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