J Korean Med Sci.  2013 Apr;28(4):569-574. 10.3346/jkms.2013.28.4.569.

Relationship between Bone Mineral Density and Moderate to Severe Chronic Kidney Disease among General Population in Korea

• Myong JP
• Kim HR
• Koo JW
• Park CY

• KMID: 1786965
• DOI: http://doi.org/10.3346/jkms.2013.28.4.569

Abstract

Recent studies in Western countries have reported a significant association between glomerular filtration rate (GFR) and bone mineral density (BMD) in the absence of dialysis among the general population. However, there have been few studies regarding renal function and BMD among Korean or Asian subjects with moderate to severe (stage 3 or 4) chronic kidney disease (MS-CKD). The aim of the present study was to investigate the association between MS-CKD and BMD in the general Korean population. BMD, serum creatinine and other measures were obtained from 3,190 subjects (1,428 males and 1,762 females; the fourth Korean National Health and Nutrition Examination Survey). GFR was estimated using the Cockcroft-Gault formula, with adjustment for body surface area. After adjustment for all variables, multiple regression analysis showed that BMD in the femur neck, total femur and lumbar spine were positively associated with eGFR in both males and females. Additional analysis showed that MS-CKD was also significantly associated with osteoporosis in both males and females (odds ratio [OR] 2.20, 95% confidence interval [CI] 1.15-4.20 in males; and OR 1.96, 95% CI 1.33-2.88 in females). Individuals with MS-CKD may be at higher risk of osteoporosis even among Asians.

Keyword

Glomerular Filtration Rate; Bone Density; Osteoporosis; Renal Insufficiency; KNHANES

MeSH Terms

Adult
Aged
*Bone Density
Creatinine/blood
Female
Femur/physiopathology
Femur Neck/physiopathology
Glomerular Filtration Rate
Humans
Lumbar Vertebrae/physiopathology
Male
Middle Aged
Nutrition Surveys
Odds Ratio
Osteoporosis/etiology
Regression Analysis
Renal Insufficiency, Chronic/complications/*physiopathology
Republic of Korea
Severity of Illness Index
Creatinine

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