J Korean Med Sci.  2008 Jun;23(3):529-532. 10.3346/jkms.2008.23.3.529.

Acute Interstitial Pneumonia in Siblings: A Case Report

• Kwon SY
• Kim JM
• Sohn MH
• Kim DS
• Kim MJ
• Cho SH

• KMID: 1786896
• DOI: http://doi.org/10.3346/jkms.2008.23.3.529

Abstract

Acute interstitial pneumonia (AIP) is a rapidly progressive condition of unknown cause that occurs in a previously healthy individual and produces the histologic findings of diffuse alveolar damage. Since the term AIP was first introduced in 1986, there have been very few case reports of AIP in children. Here we present a case of AIP in a 3-yr-old girl whose other two siblings showed similar radiologic findings. The patient was confirmed to have AIP from autopsy showing histological findings of diffuse alveolar damage and proliferation of fibroblasts. Her 3-yr-old brother was also clinically and radiologically highly suspected as having AIP, and the other asymptomatic 8-yr-old sister was radiologically suspected as having AIP.

Keyword

Lung Diseases, Interstitial; Child; Siblings

MeSH Terms

Acute Disease
Child, Preschool
Family Health
Fatal Outcome
Female
Humans
Infant
Lung Diseases, Interstitial/*pathology/*radiography
Male
Pulmonary Fibrosis/pathology/radiography
Siblings
*Tomography, X-Ray Computed

Figure

• 

  Fig. 1 Chest CT shows symmetric ground glass opacities and consolidations in both upper (A) and lower (B) lobes.

• 

  Fig. 2 Hematoxylin and Eosin stain, ×100. (A) The alveolar septal interstitium is diffusely thickened by uniform, organizing loose fibrosis. (B) The lung shows involvement of hyaline membranes as well as prominent interstitial and alveolar edema. Focal type II pneumocyte hyperplasia is present.

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