J Korean Med Sci.  2008 Feb;23(1):149-152. 10.3346/jkms.2008.23.1.149.

Secondary Thyroid Papillary Carcinoma in Osteosarcoma Patients: Report of Two Cases

• Kim MS
• Sim YS
• Lee SY
• Jeon DG

• KMID: 1786864
• DOI: http://doi.org/10.3346/jkms.2008.23.1.149

Abstract

We report two cases of papillary thyroid carcinoma occurring after the successful treatment of osteosarcoma. One of the patients was administered with several alkylating agents and topoisomerase II inhibitor as part of the primary treatment of osteosarcoma. The onset of thyroid carcinoma occurred after 5 and 12 yr after cessation of the osteosarcoma therapy. All the patients involved in this study are alive and free of their malignancies. There have been eight case reports of these two malignancies occurring in the same patient. Thyroid carcinoma rarely occurs in patients with osteosarcoma; however, vigilant surveillance and long-term follow-up should be emphasized for all survivors.

Keyword

Osteosarcoma; Thyroid Neoplasms; Neoplasms, Second Primary

MeSH Terms

Adolescent
Bone Neoplasms/*therapy
Carcinoma, Papillary/*etiology
Female
Humans
Male
Neoplasms, Second Primary/*etiology
Osteosarcoma/*therapy
Thyroid Neoplasms/*etiology

Figure

• 

  Fig. 1 (A) A plain radiograph showed pathologic fracture around the surgical neck of the right humerus. The incisional biopsy confirmed the diagnosis of osteosarcoma. (B) Pathologic examination revealed a papillary carcinoma in the right lobe of thyroid. The tumor cells were tall and their cytoplasm contained eosinophilic granules and pseudostratified nuclei in several areas (stain, H&E; original magnification, ×100).

• 

  Fig. 2 (A) An anteroposterior radiograph showed pasteurized autograft-prosthesis composite reconstruction of the proximal tibial osteosarcoma. (B) Five years after the index operation, a follow-up CT scan shows a calified nodule in the left lobe of the thyroid. (C) The tumor cells showed typical overlapping, grooved, and ground glass nuclei (stain, H&E; original magnification, ×200).

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