J Korean Med Sci.  2004 Jun;19(3):477-480. 10.3346/jkms.2004.19.3.477.

Giant Cell Malignant Fibrous Histiocytoma of the Breast: A Case Report

• Oh SJ
• Kim KM
• Hong TH
• Park WC
• Kim JS
• Jung SS

• KMID: 1786833
• DOI: http://doi.org/10.3346/jkms.2004.19.3.477

Abstract

A case of primary malignant fibrous histiocytoma of the breast is reported. The patient was a 48-yr-old woman with a huge tumor involving almost the entire left breast. The central portion of her left breast was already rotted by extensive necrosis and inflammation. She was treated by radical mastectomy and axillary lymphadenectomy to level I. Pathologic examination supported by an immunohistochemical staining confirmed the tumor as malignant fibrous histiocytoma of giant cell type. Axillary lymph nodes were free from tumor metastasis. She had not taken any postoperative adjuvant therapy. The metastasis to lungs was found 2 months after the operation, and she died within 6 months.

Keyword

Breast Neoplasms; Sarcoma; Malignant Fibrous Histiocytoma; Myxosarcoma; Histiocytic Disorders, Malignant

MeSH Terms

Breast/pathology
Breast Neoplasms/*diagnosis/*pathology
Female
Giant Cells/*pathology
Histiocytoma, Fibrous/*diagnosis/*pathology
Human
Immunohistochemistry
Lung Neoplasms/mortality/secondary
Middle Aged
Myxosarcoma/diagnosis/pathology
Necrosis
Neoplasm Metastasis
Sarcoma/diagnosis/pathology

Figure

• 

  Fig. 1 Gross finding of the tumor. The tumor involves almost the entire left breast, which is rotted by extensive necrosis and inflammation.

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  Fig. 2 Microscopic findings of the tumor. Low power (A, H&E, ×100) and high power (B, H&E, ×400) examinations show many multinucleated osteoclast-like giant cells and hyperchromatic mononuclear tumor cells.

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