J Korean Med Sci.  2004 Jun;19(3):384-389. 10.3346/jkms.2004.19.3.384.

The Effects of Antidepressant Treatment on Serum Cytokines and Nutritional Status in Hemodialysis Patients

• Lee SK
• Lee HS
• Lee TB
• Kim DH
• Koo JR
• Kim YK
• Son BK

• KMID: 1786816
• DOI: http://doi.org/10.3346/jkms.2004.19.3.384

Abstract

The aim of this study was to investigate the effects of antidepressant treatment on serum cytokines and nutritional status in hemodialysis patients. Twenty-eight hemodialysis patients with a depressed mood were given 20 mg of fluoxetine for 8 weeks. The degree of depressive symptoms, the serum levels of interleukin-1beta, interleukin- 2, interleukin-6, tumor necrosis factor-alpha, c-reactive protein, and markers of nutritional status were assessed at baseline and after treatment. The outcome was assessed in terms of response to treatment (>50% reduction in the score of the Hamilton depression rating scale). Antidepressant treatment decreased the serum level of interleukin- 1 in both response and nonresponse groups, and increased the serum level of interleukin-6 only in the response group. At baseline, the level of interleukin-6 in the response group was lower than in the nonresponse group. Antidepressant treatment also increased fat distribution significantly in the response group which might have slightly improved the nutritional status. This study suggests that antidepressant treatment improve depressive symptoms and may affect immunological functions and nutritional status in chronic hemodialysis patients with depression.

Keyword

Depression; Antidepressive Agents; Cytokines; Nutritional Status; Renal Dialysis

MeSH Terms

Adult
Antidepressive Agents, Second-Generation/*pharmacology
C-Reactive Protein/biosynthesis
Cytokines/*blood
Depression/*drug therapy
Electric Impedance
Female
Fluoxetine/*pharmacology
Human
Interleukin-1/blood
Interleukin-2/blood
Interleukin-6/blood
Male
Middle Aged
Nutrition
Renal Dialysis/*methods
Support, Non-U.S. Gov't
Treatment Outcome
Tumor Necrosis Factor/biosynthesis

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