J Korean Med Sci.
2007 Sep;22(Suppl):S159-S163. 10.3346/jkms.2007.22.S.S159.
Primary Pulmonary Ewing's Sarcoma/Primitive Neuroectodermal Tumor in a 67-year-old Man
- Affiliations
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- 1Department of Family Medicine, Korea University, College of Medicine, Seoul, Korea.
- 2Department of Pathology, Korea University, College of Medicine, Seoul, Korea.
- 3Department of Pulmonology, Korea University, College of Medicine, Seoul, Korea.
- 4Department of Diagnostic Radiology, Korea University, College of Medicine, Seoul, Korea.
- 5Department of Family Medicine, Hallym University, College of Medicine, Chunchon, Korea. rohyk@hallym.ac.kr
- KMID: 1785807
- DOI: http://doi.org/10.3346/jkms.2007.22.S.S159
Abstract
- Extraskeletal Ewing's sarcoma (EES) is a branch of neuroectodermal tumor (PNET), which is very rare soft tissue sarcoma. We report a case of EES/PNET arising is the lung of a 67-yr-old man. Computed tomography, bone scintigraphy, and positron emission tomography confirmed the mass to have a primary pulmonary origin. The mass showed positive reactivity in the Periodic Acid Schiff (PAS) stain and MIC-2 immunoreactivity in immunohistochemical stain. Fluorescence in situ hybridization (FISH) was performed, which revealed an EWSR1 (Ewing sarcoma breakpoint region 1) 22q12 rearrangement. The diagnosis was confirmed both pathologically and genetically. The mass lesion was resected, and the patient is currently undergoing chemotherapy.
Keyword
MeSH Terms
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Aged
Calmodulin-Binding Proteins/genetics
Chromosome Breakage
Chromosomes, Human, Pair 22/genetics
Diagnosis, Differential
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Lung Neoplasms/*diagnosis/genetics/metabolism/pathology
Male
Neuroectodermal Tumors, Primitive,
RNA-Binding Proteins/genetics
Sarcoma, Ewing's/*diagnosis/genetics/metabolism/pathology
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