Korean J Intern Med.  2006 Mar;21(1):57-61. 10.3904/kjim.2006.21.1.57.

Peripheral T-cell Lymphoma-Unspecified (PTCL-U) Presenting with Hypereosinophilic Syndrome and Pleural Effusions

• Choi W
• Park YH
• Paik KH
• Chang YH
• Lee SS
• Ryoo BY
• Yang SH

• KMID: 1782254
• DOI: http://doi.org/10.3904/kjim.2006.21.1.57

Abstract

Hypereosinophilic syndrome (HES) is a clinical disorder characterized by persistent eosinophilia and systemic involvement, in which a specific causative factor for the eosinophilia cannot be verified during a certain period of time. There have been only a few reported cases of this syndrome associated with malignant lymphoma. We report a case of peripheral T-cell lymphoma-unspecified with hypereosinophilic syndrome. The patient was a 42-year-old woman with an uncontrolled fever and a sore throat. Eosinophilia was observed on the peripheral blood smear. We confirmed the diagnosis by bone marrow and liver biopsies: A bone marrow aspiration demonstrated markedly increased eosinophils (24.8%), and a liver biopsy demonstrated infiltration by scattered eosinophils and atypical lymphoid cells, which were confirmed to be T-cell lymphoma cells. This case was a distinctive presentation of peripheral T-cell lymphoma with hypereosinophilic syndrome, probably due to a paraneoplastic condition.

Keyword

Hypereosinophilic syndrome; Lymphoma; T-Cell; Peripheral; Paraneoplastic syndrome

MeSH Terms

Recurrence
Pleural Effusion/*etiology
Lymphoma, T-Cell, Peripheral/complications/*diagnosis
Liver Neoplasms/complications/*diagnosis
Hypereosinophilic Syndrome/*etiology
Humans
Female
Fatal Outcome
Adult