Ann Lab Med.  2013 May;33(3):225-228. 10.3343/alm.2013.33.3.225.

Plasma Cell Myeloma Initially Presenting as Lung Cancer

• Cho SY
• Jeong JH
• Lee WI
• Lee J
• Hong IK
• Suh JT
• Lee HJ
• Yoon HJ
• Park TS

• KMID: 1781333
• DOI: http://doi.org/10.3343/alm.2013.33.3.225

Abstract

No abstract available.

MeSH Terms

Bone Marrow Cells/pathology
Bone and Bones/radionuclide imaging
Female
Humans
Lung Neoplasms/diagnosis/radiography
Middle Aged
Multimodal Imaging
Multiple Myeloma/*diagnosis/pathology/radiography
Tomography, X-Ray Computed

Figure

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  Fig. 1 Imaging studies. Computed tomography (CT) and positron emission tomography (PET)/CT findings showing the branching out lung mass (A), pleural nodules (B), and paraspinal lesions (C), which were initially interpreted to be suggestive of lung cancer with bone destruction and metastasis. PET/CT reveals multiple hypermetabolic bone lesions (D).

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  Fig. 2 Bone marrow findings. Plasma cells with eccentric nuclei and basophilic cytoplasm were predominantly observed in aspiration smears (A, Wright stain, ×1,000) and clot sections (B, H&E stain, ×1,000). The biopsy sections revealed massive infiltrations of plasma cells (B and C, H&E stain, ×400).

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  Fig. 3 Examinations of the pleural fluid and biopsy. In the cytospin of pleural fluid, plasma cells characterized by basophilic cytoplasm, eccentric nucleus and perinuclear halo were predominantly observed (A, Wright stain, ×1,000). In the pleural biopsy, homogenous infiltrations of plasma cells were identified (B, H&E stain, ×400). Lambda restriction was confirmed (C, immunohistochemical stain, ×400), while kappa was negative (D, immunohistochemical stain, ×400) in the pleural specimen.

Reference

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