Korean J Intern Med.  2013 Sep;28(5):525-537. 10.3904/kjim.2013.28.5.525.

Current evidence of effects of Helicobacter pylori eradication on prevention of gastric cancer

• Choi IJ

• KMID: 1780098
• DOI: http://doi.org/10.3904/kjim.2013.28.5.525

Abstract

Gastric cancer is the second most common cause of cancer death worldwide and is usually detected at a late stage, except in Korea and Japan where early screening is in effect. Results from animal and epidemiological studies suggest that Helicobacter pylori infection, and subsequent gastritis, promote development of gastric cancer in the infected mucosa. Relatively effective treatment regimens are available to treat H. pylori infection, and in general, mass eradication of the organism is not currently recommended as a gastric cancer prevention strategy. However, regional guidelines vary regarding the indications and recommendations for H. pylori treatment for gastric cancer prevention. In this review, we discuss the results from intervention studies, provide insight regarding current guideline recommendations, and discuss future study directions.

Keyword

Stomach neoplasms; Helicobacter pylori; Prevention and control

MeSH Terms

Anti-Bacterial Agents/*therapeutic use
Drug Therapy, Combination
Early Detection of Cancer
Evidence-Based Medicine
Gastrectomy
Gastritis/diagnosis/*drug therapy/microbiology
Helicobacter Infections/complications/diagnosis/*drug therapy/microbiology
Humans
Neoplasm Recurrence, Local
Practice Guidelines as Topic
Proton Pump Inhibitors/*therapeutic use
Risk Factors
Stomach Neoplasms/diagnosis/microbiology/*prevention & control/surgery
Treatment Outcome
Anti-Bacterial Agents
Proton Pump Inhibitors