Yonsei Med J.  2012 Jan;53(1):198-203. 10.3349/ymj.2012.53.1.198.

Lipid-Emulsion Propofol Less Attenuates the Regulation of Body Temperature than Micro-Emulsion Propofol or Sevoflurane in the Elderly

• Jeong CW
• Ju J
• Lee DW
• Lee SH
• Yoon MH

• KMID: 1779707
• DOI: http://doi.org/10.3349/ymj.2012.53.1.198

Abstract

PURPOSE
Anesthesia and surgery commonly cause hypothermia, and this caused by a combination of anesthetic-induced impairment of thermoregulatory control, a cold operation room environment and other factors that promote heat loss. All the general anesthetics markedly impair normal autonomic thermoregulatory control. The aim of this study is to evaluate the effect of two different types of propofol versus inhalation anesthetic on the body temperature.
MATERIALS AND METHODS
In this randomized controlled study, 36 patients scheduled for elective laparoscopic gastrectomy were allocated into three groups; group S (sevoflurane, n=12), group L (lipid-emulsion propofol, n=12) and group M (micro-emulsion propofol, n=12). Anesthesia was maintained with typical doses of the study drugs and all the groups received continuous remifentanil infusion. The body temperature was continuously monitored after the induction of general anesthesia until the end of surgery.
RESULTS
The body temperature was decreased in all the groups. The temperature gradient of each group (group S, group L and group M) at 180 minutes from induction of anesthesia was 2.5+/-0.6degrees C, 1.6+/-0.5degrees C and 2.3+/-0.6degrees C, respectively. The body temperature of group L was significantly higher than that of group S and group M at 30 minutes and 75 minute after induction of anesthesia, respectively. There were no temperature differences between group S and group M.
CONCLUSION
The body temperature is maintained at a higher level in elderly patients anesthetized with lipid-emulsion propofol.

Keyword

Body temperature; hypothermia; lipid emulsion; propofol; aquafol

MeSH Terms

Aged
Aging
Anesthesia, General/*methods
Anesthetics, Combined/administration & dosage
Anesthetics, Inhalation/*administration & dosage
Anesthetics, Intravenous/*administration & dosage
Body Temperature/*drug effects
Body Temperature Regulation/drug effects
Fat Emulsions, Intravenous
Female
Humans
Male
Methyl Ethers/*administration & dosage
Middle Aged
Propofol/*administration & dosage

Figure

• 

  Fig. 1 This figure shows the body temperature during anesthesia. The body temperatures of lipid-emulsion propofol group (Group L) were significantly higher than that of the sevoflurane (Group S) and micro-emulsion groups (Group M). It started from 30 minutes and 75 minutes after induction of anesthesia, respectively. Group S: sevoflurane group, Group L: lipid-emulsion propofol group, Group M: micro-emulsion propofol group. *p<0.05 compared with Group S, and †p<0.05 compared with Group M.

• 

  Fig. 2 This figure shows the mean arterial pressure (MAP) and heart rate (HR) during anesthesia. There are no significant differences between the groups. Group S: sevoflurane group, Group L: lipid-emulsion propofol group, Group M: micro-emulsion propofol group.

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