Yonsei Med J.  2012 Jan;53(1):43-52. 10.3349/ymj.2012.53.1.43.

Statistical Mapping Analysis of Brain Metabolism in Patients with Subcortical Aphasia after Intracerebral Hemorrhage: A Pilot Study of F-18 FDG PET Images

• Kim YW
• Kim HS
• An YS

• KMID: 1779685
• DOI: http://doi.org/10.3349/ymj.2012.53.1.43

Abstract

PURPOSE
This study was aimed to evaluate the brain metabolism in patients with subcortical aphasia after intracerebral hemorrhage (ICH) and the relationship between the severity of aphasia and regional brain metabolism, by using statistical mapping analysis of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) images.
MATERIALS AND METHODS
Sixteen right-handed Korean speaking patients with subcortical aphasia following ICH were enrolled. All patients underwent Korean version of the Western Aphasia Battery and the brain F-18 FDG PET study. Using statistical parametric mapping analysis, we compared the brain metabolisms shown on F-18 FDG PET from 16 patients with subcortical aphasia and 16 normal controls. In addition, we investigated the relationship between regional brain metabolism and the severity of aphasia using covariance model.
RESULTS
Compared to the normal controls, subcortical aphasia after ICH showed diffuse hypometabolism in the ipsilateral cerebrum (frontal, parietal, temporal, occipital, putamen, thalamus) and in the contralateral cerebellum (P corrected <0.001), and showed diffuse hypermetabolism in the contralateral cerebrum (frontal, parietal, temporal) and in the ipsilateral cerebellum (P FDR corrected <0.001). In the covariance analysis, increase of aphasia quotient was significantly correlated with increased brain metabolism in the both orbitofrontal cortices, the right hippocampal and the right parahippocampal cortices (P uncorrected <0.01).
CONCLUSION
Our findings suggest that frontal, parietal, and temporal cortices, which are parts of neural network for cognition, may have a supportive role for language performance in patients with subcortical aphasia after ICH.

Keyword

Brain metabolism; subcortical aphasia after intracerebral hemorrhage; statistical mapping analysis

MeSH Terms

Adult
Aged
Aphasia/etiology/metabolism/*radionuclide imaging
Brain/metabolism/*radionuclide imaging
Brain Mapping/*methods
Cerebral Hemorrhage/complications/metabolism/*radionuclide imaging
Female
Fluorodeoxyglucose F18/*diagnostic use
Humans
Male
Middle Aged
Pilot Projects
Positron-Emission Tomography/*methods

Figure

• 

  Fig. 1 The brain computed tomography or magnetic resonance images findings of all patients with subcortical aphasia after intracerebral hemorrhage.

• 

  Fig. 2 The brain F-18 fluorodeoxyglucose positron emission tomography images of all patients with subcortical aphasia after intracerebral hemorrhage.

• 

  Fig. 3 Statistical parametric maps showing spatial distributions of significant decreases in cerebral glucose metabolism in patients with subcortical aphasia after intracerebral hemorrhage compared to controls. Displayed voxels are significant at P FDR corrected<0.001.

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  Fig. 4 Statistical parametric maps showing spatial distributions of significant increases in cerebral glucose metabolism in patients with subcortical aphasia after intracerebral hemorrhage compared to controls. Displayed voxels are significant at P FDR corrected<0.001.

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  Fig. 5 Statistical parametric maps showing correlations of increased aphasia quotients of language performance with increased changes in regional cerebral glucose metabolism in subcortical aphasia after intracerebral hemorrahge. Displayed voxels are significant at P uncorrected<0.01. R, right; L, left.

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