J Korean Med Sci.  2004 Dec;19(6):901-903. 10.3346/jkms.2004.19.6.901.

Pulmonary Metastases of Uterine Endometrial Stromal Sarcoma: Diffuse Micronodular and Ground Glass Opacities: A Case Report

• Kim GY
• Sung CO
• Han J
• Park JO
• Lee KS

• KMID: 1778578
• DOI: http://doi.org/10.3346/jkms.2004.19.6.901

Abstract

Pulmonary metastases of uterine endometrial stromal sarcoma (ESS) are un com-mon. The patterns of uterine ESS metastasis to the lung are multiple pulmonary nodules, single nodule, or cystic lesions. Pulmonary intraalveolar micronodular metastases of uterine ESS are unusual and have not been reported. We experienced a case of metastatic uterine ESS presenting as pulmonary diffuse micronodules with ground glass opacities on chest computed tomography of a 37-yr-old woman who previously underwent hysterectomy due to low grade ESS of the uterus four years ago. The histologic findings of video assisted thoracotomy biopsy showed numerous intraalveolar polypoid micronodules protruding from the alveolar septums. All tumor nodules were composed of short spindle cells arranged in ill-defined whorls, and nuclear feature and sparse cytoplasm were seen in uterine ESS. Immunohistochemically, these cells showed strong nuclear staining for estrogen receptor and progesterone receptor, and diffuse cytoplasmic staining for CD10.

Keyword

Sarcoma, Endometrial Stromal; Neoplasm Metastasis; Lung Neoplasms

MeSH Terms

Adult
Endometrial Neoplasms/*pathology/radiography
Female
Humans
Lung Neoplasms/*pathology/radiography/*secondary
Sarcoma, Endometrial Stromal/*pathology/radiography/*secondary

Figure

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  Fig. 1 Chest computed tomography shows diffuse micronodules and ground glass opacities in both lung fields.

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  Fig. 2 Histologic section shows numerous micronodules in the alveolar spaces (H&E, ×1).

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  Fig. 3 Microscopically, nodules consist of short spindle cells arranged in ill-defined whorls. The tumor cells have bland nuclear features and eosinophilic cytoplasm (H&E, ×200). Inset shows nuclear immunoreactivity for estrogen receptor (×400).

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