Korean J Hepatol.  2007 Dec;13(4):530-542. 10.3350/kjhep.2007.13.4.530.

Five-year Survival Analysis of a Cohort of Hepatocellular Carcinoma Patients Who Treated at the National Cancer Center, Korea

• Park KW
• Park JW
• Kim TH
• Choi JI
• Kim SH
• Park HS
• Park SJ
• Lee WJ
• Shin HL
• Kim CM

• KMID: 1776829
• DOI: http://doi.org/10.3350/kjhep.2007.13.4.530

Abstract

BACKGROUND AND AIMS: We investigated the five-year survival outcomes of a large cohort of hepatocellular carcinoma (HCC) patients who were treated at a single institute, and this is a follow-up study of a previous report. METHODS: Nine hundred four HCC patients who were treated at the National Cancer Center Korea were enrolled and they were followed till February 2007. RESULTS: The mean age of the patients was 56.0 years and 731 patients were male. Six hundred seventy-seven (74.9%) patients died and the overall 5-year survival rate (5-YSR) was 23.9%. The 5-YSRs of the patients with modified UICC stage I, II and III were 61.2%, 54.4% and 18.4%, respectively, and the median survival time was 4.3 and 3.7 months for the stage IVa and IVb patients, respectively. For the analysis of the treatment modality, surgical resection showed significantly better outcomes for the five-year survival as compared with transcatheter arterial chemoembolization (TACE) for Child-Pugh A patients with modified UICC stage I or II disease (80.1% vs 52.8%, respectively, P<.001), or stage III disease (60.7% vs 17.0%, respectively, P<.001). For patients with advanced stage IVb disease, TACE, systemic chemotherapy and radiotherapy increased the median survival period more than conservative management for the Child-Pugh class A patients. The serum alpha-fetoprotein level, portal vein tumor thrombosis, the Child-Pugh class, the tumor stage, the tumor type and symptoms were related to the prognosis. CONCLUSIONS: This study presented, for the first time, the 5-YSRs of a cohort of HCC patients.

Keyword

Carcinoma, hepatocellular; Survival; Prognosis; Treatment; Treatment outcome

MeSH Terms

Aged
Carcinoma, Hepatocellular/etiology/*mortality/surgery
Chemoembolization, Therapeutic
Cohort Studies
Combined Modality Therapy
Female
Humans
Korea
Liver Neoplasms/etiology/*mortality/surgery
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Radiotherapy, Conformal
Severity of Illness Index
Survival Rate