Korean J Intern Med.
2011 Jun;26(2):137-144. 10.3904/kjim.2011.26.2.137.
Endoscopic Cryotherapy of Lung and Bronchial Tumors: A Systematic Review
- Affiliations
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- 1National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.
- 2Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea.
- 3Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea School of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea School of Medicine, Suwon, Korea.
- 5Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
- 6Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea. parkkj@ajou.ac.kr
- KMID: 1776585
- DOI: http://doi.org/10.3904/kjim.2011.26.2.137
Abstract
- BACKGROUND/AIMS
We made a systematic review and evaluation of endoscopic cryotherapy of endobronchial tumors, investigating safety and efficacy.
METHODS
Qualified studies regarding endoscopic cryotherapy of lung tumors were systemically evaluated using available databases according to predefined criteria.
RESULTS
In total, 16 publications were included in the final assessment. A narrative synthesis was performed because a formal meta-analysis was not viable due to the lack of controlled studies and study heterogeneity. Overall success rates for significant recanalization of the obstruction were approximately 80%, although they varied, depending on disease status in the patient population. Complications from the procedure developed in 0-11.1% of cases, most of which were minor and controlled by conservative management. Although limited data were available on comprehensive functional assessment, some studies showed that respiratory symptoms, pulmonary function tests, and performance status were significantly improved.
CONCLUSIONS
Endoscopic cryotherapy was found to be a safe and useful procedure in the management of endobronchial tumors although its efficacy and appropriate indications have yet to be determined in well-designed controlled studies.
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