Korean J Intern Med.  2013 May;28(3):356-360. 10.3904/kjim.2013.28.3.356.

Synephrine-containing dietary supplement precipitating apical ballooning syndrome in a young female

Affiliations
  • 1Division of Cardiology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. bkhong@yuhs.ac
  • 2Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea.
  • 3Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Apical ballooning syndrome (ABS) is a unique reversible cardiomyopathy that is frequently precipitated by emotional or physical stress. In addition, the few drugs reported to precipitate ABS were either illegal or strictly controlled for medical use. This paper reports a case of ABS precipitated by a dietary supplement. Our case accentuates the potential risk of dietary supplements containing synephrine, which is uncontrolled and available to the general public. Therefore, the Korea Food and Drug Administration should regulate these dietary supplements, and warn healthcare workers and the general public of the potential hazards of the indiscriminate abuse of dietary supplements.

Keyword

Takotsubo cardiomyopathy; Dietary supplements; Synephrine

MeSH Terms

Adrenergic alpha-Agonists/*adverse effects
Dietary Supplements/adverse effects
Female
Humans
Synephrine/*adverse effects
Takotsubo Cardiomyopathy/*chemically induced
Young Adult
Adrenergic alpha-Agonists
Synephrine
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