Korean J Gastroenterol.  2011 Feb;57(2):67-81. 10.4166/kjg.2011.57.2.67.

Guidelines for the Treatment of Functional Dyspepsia

• Jee SR
• Jung HK
• Min BH
• Choi KD
• Rhee PL
• Kang YW
• Lee SI
• The Korean Society of Neurogastroenterology and Motility

• KMID: 1775838
• DOI: http://doi.org/10.4166/kjg.2011.57.2.67

Abstract

Functional dyspepsia (FD) is defined as the presence of symptoms thought to originate in the gastroduodenal area, in the absence of any organic, systemic, or metabolic disease that is likely to explain the symptoms. Based on the available evidence and consensus opinion, thirteen consensus statements for the treatment of FD were developed using the modified Delphi approach. Proton pump inhibitor, prokinetics, and histamine 2 receptor antagonists are effective for the treatment of FD. Mucosal protecting agents, fundus relaxant, and drugs for visceral hypersensitivity can improve symptoms in FD. Antacids and antidepressants may help improving symptoms in FD. Comparing endoscopy with 'test and treat' of Helicobacter pylori, endoscopy may be more effective initial strategy for managing patients with FD in Korea given high incidence of gastric cancer and low cost of endoscopy. Helicobacter pylori eradication can be one of the therapeutic options for patients with FD. Psychotherapy is effective for those who have severe symptoms and refractoriness. Further studies are strongly needed to develop better treatment strategies for Korean patients with FD.

Keyword

Functional; Dyspepsia; Treatment; Guideline

MeSH Terms

Antacids/therapeutic use
Anti-Ulcer Agents/therapeutic use
Antidepressive Agents/therapeutic use
Dyspepsia/diet therapy/*therapy
Gastroscopy
Helicobacter Infections/drug therapy
Helicobacter pylori
Histamine H2 Antagonists/therapeutic use
Humans
Proton Pump Inhibitors/therapeutic use
Psychotherapy
Serotonin 5-HT3 Receptor Antagonists/therapeutic use
Vasoconstrictor Agents/therapeutic use

Figure

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  Fig. 1. Flow chart for searching strategy.

Reference

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