Gut Liver.  2014 May;8(3):324-328.

Glutamine-Supplemented Parenteral Nutrition and Probiotics in Four Adult Autoimmune Enteropathy Patients

• Xu RY
• Wan YP
• Zhou YQ
• Lu LP
• Chen ZQ
• Wu YJ
• Cai W

Abstract

To evaluate the effects of glutamine-supplemented parenteral nutrition (PN) and probiotics in adult autoimmune enteropathy (AIE) patients. Four adult AIE patients were identified from April 2006 to January 2012. Clinical and nutritional data were obtained from the patients' medical records. Glutamine-supplemented PN started immediately when the AIE diagnosis was confirmed. The total PN duration was 351 days. According to the PN prescription, the average caloric intake ranged from 20 to 25 kcal/kg/day, and the protein intake ranged from 1.2 to 1.5 g/kg/day. Alanyl-glutamine (20 g/day) was administered to AIE patients for 4 weeks followed by a 2-week break, and this treatment schedule was repeated when PN lasted for more than 6 weeks. Body weight gain and an increased serum albumin level were achieved after PN, and defecation frequency and quality also improved. Each patient received oral supplements, 250 mL of Ensure and two probiotics capsules (each capsule containing 0.5x10(8) colonies) three times a day when enteral nutrition started. Three AIE patients were successfully weaned off PN, and one patient died of pneumonia. Glutamine-supplemented PN and probiotics show promise in managing patients with AIE and related malnutrition.

Keyword

Autoimmune enteropathy; Malnutrition; Parenteral nutrition; Probiotics; Glutamine

MeSH Terms

Adult
Bifidobacterium
Enterococcus faecalis
Female
Glutamine/*administration & dosage
Humans
Lactobacillus acidophilus
Length of Stay
Male
Malnutrition/therapy
Parenteral Nutrition/*methods
Polyendocrinopathies, Autoimmune/*therapy
Probiotics/*administration & dosage
Young Adult
Glutamine