Gut Liver.  2014 May;8(3):277-281.

Low Pepsinogen I Level Predicts Multiple Gastric Epithelial Neoplasias for Endoscopic Resection

• Park SY
• Lim SO
• Ki HS
• Jun CH
• Park CH
• Kim HS
• Choi SK
• Rew JS

Abstract

BACKGROUND/AIMS
Synchronous/metachronous gastric epithelial neoplasias (GENs) in the remaining lesion can develop at sites other than the site of endoscopic resection. In the present study, we aimed to investigate the predictive value of serum pepsinogen for detecting multiple GENs in patients who underwent endoscopic resection.
METHODS
In total, 228 patients with GEN who underwent endoscopic resection and blood collection for pepsinogen I and II determination were evaluated retrospectively.
RESULTS
The mean period of endoscopic follow-up was 748.8+/-34.7 days. Synchronous GENs developed in 46 of 228 (20.1%) and metachronous GENs in 27 of 228 (10.6%) patients during the follow-up period. Multiple GENs were associated with the presence of pepsinogen I <30 ng/mL (p<0.001). Synchronous GENs were associated with the presence of pepsinogen I <30 ng/mL (p<0.001).
CONCLUSIONS
Low pepsinogen I levels predict multiple GENs after endoscopic resection, especially synchronous GENs. Cautious endoscopic examination prior to endoscopic resection to detect multiple GENs should be performed for these patients.

Keyword

Pepsinogens; Stomach; Neoplasms

MeSH Terms

Female
Gastroscopy
Humans
Male
Middle Aged
Neoplasms, Glandular and Epithelial/*diagnosis/surgery
Neoplasms, Multiple Primary/*diagnosis/surgery
Pepsinogen A/*deficiency
Predictive Value of Tests
Retrospective Studies
Stomach Neoplasms/*diagnosis/surgery
Pepsinogen A