Gut Liver.
2014 Jan;8(1):94-101.
Differential Expression of E-Cadherin, beta-Catenin, and S100A4 in Intestinal Type and Nonintestinal Type Ampulla of Vater Cancers
- Affiliations
-
- 1Department of Pathology, Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea.
- 2Department of Internal Medicine, Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea. smpark@chungbuk.ac.kr
- 3Department of Surgery, Medical Research Institute, Chungbuk National University College of Medicine, Cheongju, Korea.
- 4Department of Pathology, Research Center, Aerospace Medical Center, Cheongju, Korea.
- 5Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
- 6Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
- 7Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
- 8Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
Abstract
- BACKGROUND/AIMS
Epithelial-mesenchymal transition (EMT)-related proteins may exhibit differential expression in intestinal type or pancreatobiliary type ampulla of Vater carcinomas (AVCs). We evaluated the expression of E-cadherin, beta-catenin, and S100A4 in intestinal and nonintestinal type AVCs and analyzed their relationships with clinicopathological variables and survival.
METHODS
A clinicopathological review of 105 patients with AVCs and immunohistochemical staining for E-cadherin, beta-catenin, and S100A4 were performed. The association between clinicopathological parameters, histological type, and expression of EMT proteins and their effects on survival were analyzed.
RESULTS
Sixty-five intestinal type, 35 pancreatobiliary type, and five other types of AVCs were identified. The severity of EMT changes differed between the AVC types; membranous loss of E-cadherin and beta-catenin was observed in nonintestinal type tumors, whereas aberrant nonmembranous beta-catenin expression was observed in intestinal type tumors. EMT-related changes were more pronounced in the invasive tumor margin than in the tumor center, and these EMT-related changes were related to tumor aggressiveness. Among the clinicopathological parameters, a desmoplastic reaction was related to overall survival, and the reaction was more severe in nonintestinal type than in intestinal type AVCs.
CONCLUSIONS
Dysregulation of E-cadherin, beta-cadherin, and S100A4 expression may play a role in the carcinogenesis and tumor progression of AVCs.
Keyword
MeSH Terms
-
Aged
Aged, 80 and over
Ampulla of Vater/*metabolism
Cadherins/metabolism
Common Bile Duct Neoplasms/classification/*metabolism
Disease-Free Survival
Female
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
S100 Proteins/metabolism
Tumor Markers, Biological/*metabolism
beta Catenin/metabolism
Cadherins
S100 Proteins
Tumor Markers, Biological
beta Catenin
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