Korean J Gastroenterol.  2009 Nov;54(5):285-297. 10.4166/kjg.2009.54.5.285.

Guidelines of Treatment for Non-bleeding Peptic Ulcer Disease

• Cheung DY
• Jung HY
• Song HJ
• Jung SW
• Jung HC
• Korean College of Helicobacter and Upper Gastrointestinal Research
• Korean Association of Gastroenterology

• KMID: 1767732
• DOI: http://doi.org/10.4166/kjg.2009.54.5.285

Abstract

Over the past century, since the introduction of non steroidal anti-inflammatory drugs (NSAID), antacid, histamine H2-receptor antagonists (H2RA), proton pump inhibitors (PPI), and discovery of Helicobacter pylori infection, the paradigm of peptic ulcer disease has changed with marked decrease in morbidity and mortality. However, peptic ulcer disease still occupies a position as a major health problem with increase of aged population and NSAIDs usage. In daily general practice, the management of peptic ulcer disease is directed according to the presence of bleeding or not. For non-bleeding peptic ulcer disease, proper acid suppression and the correction of underlying causes such as Helicobacter pylori infection and NSAID use is the main stay of treatment. Though a complete understanding of pathophysiology and a perfect treatment strategy are still a challenge, this guideline aims to provide practical recommendations based on evidences or consensus of experts through in-depth literature review and expert meeting.

Keyword

Peptic ulcer; Non-bleeding; Treatment

MeSH Terms

Antacids/toxicity
Anti-Inflammatory Agents, Non-Steroidal/toxicity
Anti-Ulcer Agents/therapeutic use
Bismuth/therapeutic use
Helicobacter Infections/diagnosis/drug therapy
Helicobacter pylori
Histamine Antagonists/therapeutic use
Humans
Peptic Ulcer/*drug therapy
Proton Pump Inhibitors/therapeutic use