Korean J Gastroenterol.  2009 Nov;54(5):269-278. 10.4166/kjg.2009.54.5.269.

Diagnosis and Treatment Guidelines for Helicobacter pylori Infection in Korea

• Kim N
• Kim JJ
• Choe YH
• Kim HS
• Kim JI
• Chung IS
• Korean College of Helicobacter and Upper Gastrointestinal Research
• Korean Association of Gastroenterology

• KMID: 1767726
• DOI: http://doi.org/10.4166/kjg.2009.54.5.269

Abstract

Eleven years has passed since the guideline of the Korean College of Helicobacter and Upper Gastrointestinal Research group for H. pyori infection was produced in 1998. During this period the research for H. pyori has much progressed that H. pyori is now regarded as the major cause of gastric cancer. The seroprevalence of H. pyori in Korea was found to be decreased especially below the age of 40's and in the area of Seoul.Gyeonggi province, and annual reinfection rate of H. pyori has decreased up to 2.94%. In the aspect of diagnostic tests of H. pyori the biopsy is recommended in the body instead of antrum in the subjects with atrophic gastritis and/or intestinal metaplasia for the modified Giemsa staining or Warthin Starry silver staining. The urea breath test is the test of choice to confirm eradication when follow-up endoscopy is not necessary. Definite indication for H. pyori eradication is early gastric cancer in addition to the previous indications of peptic ulcer including scar and Marginal zone B cell lymphoma (MALT type). Treatment is also recommended for the relatives of gastric cancer patient, unexplained iron deficiency anemia, and chronic idiopathic thrombocytopenic purpura. One or two week treatment of proton pump inhibitor (PPI) based triple therapy consisting of one PPI and two antibiotics, clarithromycin and amoxicillin, is recommended as the first line treatment regimen. In the case of treatment failure, one or two weeks of quadruple therapy (PPI+metronidazole+tetracycline+bismuth) is recommended. Herein, Korean College of Helicobactor and Upper Gastrointestinal Research proposes a diagnostic and treatment guideline based on currently available evidence.

Keyword

Helicobactor pylori; Diagnosis; Treatment; Guideline

MeSH Terms

Amoxicillin/therapeutic use
Antacids/therapeutic use
Anti-Infective Agents/therapeutic use
Bismuth/therapeutic use
Breath Tests
Clarithromycin/therapeutic use
Enzyme-Linked Immunosorbent Assay
Gastroscopy
Helicobacter Infections/*diagnosis/*drug therapy
*Helicobacter pylori
Humans
Metronidazole/therapeutic use
Peptic Ulcer/diagnosis
Proton Pump Inhibitors/therapeutic use
Stomach Neoplasms/diagnosis
Tetracycline/therapeutic use