Korean J Anesthesiol.  2010 Aug;59(2):82-86. 10.4097/kjae.2010.59.2.82.

The clinical effective dose of rocuronium for lightwand tracheal intubation after induction with alfentanil, propofol, and low concentrations of sevoflurane

• Park HY
• Lee D
• Lee KC
• Kim SH

• KMID: 1766367
• DOI: http://doi.org/10.4097/kjae.2010.59.2.82

Abstract

BACKGROUND
The aim of this study was to determine the clinical effective dose of rocuronium for tracheal intubation using a lightwand after induction with propofol, alfentanil, and a low concentration of sevoflurane.
METHODS
Twenty-eight adults scheduled to undergo elective surgery lasting less than one hour were enrolled in this study. All patients received alfentanil (10 microgram/kg) and propofol (1.5 mg/kg) for the induction of anesthesia. Tracheal intubation using a lightwand was attempted 3 minutes after administering rocuronium and mask ventilation with 2 vol% of sevoflurane. The initial rocuronium dose was 0.5 mg/kg. The rocuronium dose for consecutive patients, determined by Dixon's up-and-down method, was increased or decreased by 0.05 mg/kg according to the result of the previous patient. The mean arterial pressure and heart rate were recorded before induction, 1 min before intubation, 1 and 2 min after intubation.
RESULTS
The 50% clinical effective dose (cED(50)) of rocuronium for tracheal intubation using a lightwand was 0.20 +/- 0.05 mg/kg according to Dixon's up and down method. Isotonic regression revealed the cED(50) and cED(95) (95% confidence intervals) to be 0.20 mg/kg (0.10-0.3 mg/kg) and 0.35 mg/kg (0.16-0.49 mg/kg), respectively.
CONCLUSIONS
The cED(50) and cED(95) of rocuronium for tracheal intubation using the lightwand were 0.20 mg/kg and 0.35 mg/kg, respectively, after induction with alfentanil, propofol, and a low concentration of sevoflurane.

Keyword

Dixon's up-and-down method; Lightwand; Rocuronium

MeSH Terms

Adult
Alfentanil
Androstanols
Anesthesia
Arterial Pressure
Heart Rate
Humans
Intubation
Masks
Methyl Ethers
Propofol
Ventilation
Alfentanil
Androstanols
Methyl Ethers
Propofol