Korean J Anesthesiol.  2008 Apr;54(4):422-426. 10.4097/kjae.2008.54.4.422.

Comparison between Bolus Injection and Continuous Infusion of Ondansetron on Nausea and Vomiting in Intravenous, Patient-controlled Analgesia after Laparoscopic-assisted Vaginal Hysterectomy using Propofol and Remifentanil Anesthesia

• Song SY
• Kim HT
• Chung JY

• KMID: 1763280
• DOI: http://doi.org/10.4097/kjae.2008.54.4.422

Abstract

BACKGROUND: The aim of this study was to evaluate the effect of continuous infusion of ondansetron compared with bolus injection on the incidence of postoperative nausea and vomiting (PONV) in intravenous, patient-controlled analgesia (PCA).
METHODS
Sixty three women undergoing laparoscopic-assisted vaginal hysterectomy were randomly allocated according to the method of ondansetron administration: bolus injection of ondansetron (8 mg) after the operation (Bolus group, n = 21); continuous infusion after ondansetron (8 mg) mixed to PCA (PCA 8 mix group, n = 22); and continuous infusion after ondansetron (16 mg) mixed to PCA (PCA 16 mix group, n = 20). The PONV were measured at 1 hr, 6 hr, 24 hr and 48 hr after operation and pain scores (visual analog scale, VAS) were checked.
RESULTS
The incidence of PONV during 48 hr in the Bolus group (23.8%) and PCA 16 mix group (20.0%) were significantly lower than PCA 8 mix group (54.5%) (P < 0.05). The three groups showed similar VAS pain scores.
CONCLUSIONS
Our results suggest that continuous infusion of ondansetron 16 mg is as effective as a bolus injection of ondansetron (8 mg) at preventing PONV in high-risk patients.

Keyword

continuous infusion; laparoscopic assisted vaginal hysterctomy; ondansetron; patient-controlled analgesia; postoperative nausea and vomiting (PONV)

MeSH Terms

Analgesia, Patient-Controlled
Anesthesia
Arabinonucleotides
Cytidine Monophosphate
Female
Humans
Hysterectomy, Vaginal
Incidence
Nausea
Ondansetron
Passive Cutaneous Anaphylaxis
Piperidines
Postoperative Nausea and Vomiting
Propofol
Vomiting
Arabinonucleotides
Cytidine Monophosphate
Ondansetron
Piperidines
Propofol