Korean J Intern Med.
2002 Mar;17(1):73-77.
A Case of Neurotoxicity Following 5-Fluorouracil-based Chemotherapy
- Affiliations
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- 1Department of Internal Medicine Korea Cancer Center Hospital, Seoul, Korea.
- 2Department of Clinical Pathology Korea Cancer Center Hospital, Seoul, Korea.
Abstract
- 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent. However, its neurotoxicity is rare and not well recognized. We report a case of 5-FU neurotoxicity with organic brain syndrome and progression to multifocal leukoencephalopathy in a 44-year-old male patient having malignant gast- rointestinal stromal tumor. 5-FU-induced neurotoxicity should, therefore, be considered as an important differential diagnosis in cancer patients with neurological abnormality and history of chemotherapy.
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