Yonsei Med J.  1983 Jun;24(1):83-86. 10.3349/ymj.1983.24.1.83.

Hereditary Spastic Paraplegia

• Choi IS
• Cho HK
• Kim KW

• KMID: 1758491
• DOI: http://doi.org/10.3349/ymj.1983.24.1.83

Abstract

Hereditary spastic paraplegia (HSP) is a rare hereditary disorder and becomes clinically apparent during adolescence or in childhood and progresses s1owly throughout the adult years with a variability in the severity of expression. We experienced 3 cases of hereditary spastic paraplegia. Cases 1 and 2, which were pure HSP, had only the signs and symptoms of corticospinal tract involvement with the positive family history, and case 3, which was a complicated case of HSP, had distal muscle wasting, dysarthria, signs and symptoms of the corticospinal tracts, and a positive family history. All are thought to be inherited in an autosomal dominant pattern.

Keyword

Hereditary spastic paralysis; pure HSP; complicated HSP

MeSH Terms

Adult
Female
Human
Male
Middle Age
Muscle Spasticity/genetics
Paraplegia/genetics*