Clin Mol Hepatol.  2012 Jun;18(2):195-202. 10.3350/cmh.2012.18.2.195.

Clinical impacts of hazardous alcohol use and obesity on the outcome of entecavir therapy in treatment-naive patients with chronic hepatitis B infection

• Chung WG
• Kim HJ
• Choe YG
• Seok HS
• Chon CW
• Cho YK
• Kim BI
• Koh YY

• KMID: 1743727
• DOI: http://doi.org/10.3350/cmh.2012.18.2.195

Abstract

BACKGROUND/AIMS
The aim of this study was to analyze the clinical impacts of obesity and hazardous alcohol use on the outcome of entecavir (ETV) therapy in chronic hepatitis B (CHB) patients.
METHODS
The medical records of 88 treatment-naive patients who were diagnosed with CHB and received ETV between March 2007 and September 2009 were analyzed retrospectively. Body mass index (BMI) values and Alcohol Use Disorders Identification Test (AUDIT) scores were obtained at 6 months after the initiation of ETV (0.5 mg daily) treatment.
RESULTS
A BMI of 25 kg/m2 or more was recognized as an indicator of obesity, and a total AUDIT score of 8 or more was recognized as an indicator of hazardous alcohol use. Of the cohort, 24 patients (27.3%) were obese and 17 (19.3%) were hazardous alcohol users. The rate of seroconversion, alanine aminotransferase (ALT) normalization, and hepatitis B virus (HBV)-DNA negativity (<300 copies/mL) at 3, 6, and 12 months of treatment did not differ significantly between the normal-BMI and high-BMI groups. Moreover, the rate of seroconversion and HBV-DNA negativity at 3, 6, and 12 months of treatment did not differ significantly between the nonhazardous and hazardous alcohol users. However, the frequency of ALT normalization at 12 months was significantly lower among hazardous alcohol users (91.5% vs. 70.6%; P=0.033).
CONCLUSIONS
Obesity and hazardous alcohol drinking have no significant impact on the outcome of ETV treatment. However, the ALT normalization rate at 12 months after initiation of ETV treatment was significantly lower among the hazardous alcohol users.

Keyword

Alcohol; Entecavir; Hepatitis B; Obesity; Treatment efficacy

MeSH Terms

Adult
Alanine Transaminase/blood
*Alcohol Drinking
Antiviral Agents/*therapeutic use
Body Mass Index
Cohort Studies
DNA, Viral/analysis
Female
Guanine/*analogs & derivatives/therapeutic use
Hepatitis B virus/genetics
Hepatitis B, Chronic/complications/*drug therapy
Humans
Male
Middle Aged
Multivariate Analysis
Obesity/complications/*diagnosis
Predictive Value of Tests
Retrospective Studies
Treatment Outcome