Cancer Res Treat.  2005 Feb;37(1):37-43.

A Preliminary Results of a Randomized Trial Comparing Monthly 5-flourouracil and Cisplatin to Weekly Cisplatin Alone Combined with Concurrent Radiotherapy for Locally Advanced Cervical Cancer

• Kim YS
• Shin SS
• Choi EK
• Kim JH
• Ahn SD
• Lee SW
• Park HJ
• Kim YT
• Mok JE
• Nam JH

Abstract

PURPOSE
To determine the superior chemotherapeutic regimen between monthly 5-FU plus cisplatin (FP) and weekly cisplatin alone in concurrent chemoradiotherapy for locally advanced cervical cancer, the compliance of treatment, response, survival and toxicities were analyzed between the two arms. MATERIALS AND METHODS: Between March 1998 and December 2001, 61 patients with locally advanced cervical cancer (stage IIB through IVA) and negative para-aortic lymph nodes were randomly assigned to either `monthly FP' (arm I, n=34) or `weekly cisplatin' (arm II, n=27) with concurrent radiotherapy. The patients of arm I received FP (5-FU 1, 000 mg/m2/day+cisplatin 20 mg/m2/day, for 5 days, for 3 cycles at 4 week intervals) and those of arm II received cisplatin (30 mg/m2/day, for 6 cycles at 1 week intervals) with concurrent radiotherapy. The radiotherapy consisted of 41.4~50.4 Gy external beam irradiation in 23~28 fractions to the whole pelvis, with high dose rate brachytherapy delivering a dose of 30~35 Gy in 6~7 fractions to point A. During the brachytherapy, a parametrial boost was delivered. The median follow-up period for survivors was 44 months. RESULTS: The compliance of treatment in monthly FP weekly cisplatin arms were 62 and 81%, respectively. The complete response rates at 3 months were 96 and 88% in arms I and II, respectively. The 4-year overall survival and disease free survival rates were 64 and 54% in the arm I and 77 and 66% in the arm II, respectively. The incidence of hematologic toxicity more than grade 2 was 29% in the arm I and 15% in the arm II. Only one patient in arm I experienced grade 3 gastrointestinal toxicity. No severe genitourinary toxicity was observed. CONCLUSION: No significant difference was observed in the compliance, responses, survival rates and acute toxicities between the two treatment arms. More patients and further follow up will be required.

Keyword

Randomized trials; Cervical neoplasm; Concurrent chemoradiotherapy

MeSH Terms

Arm
Brachytherapy
Chemoradiotherapy
Cisplatin*
Compliance
Disease-Free Survival
Fluorouracil
Follow-Up Studies
Humans
Incidence
Lymph Nodes
Pelvis
Radiotherapy*
Survival Rate
Survivors
Uterine Cervical Neoplasms*
Cisplatin
Fluorouracil

Figure

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  Fig. 1 Treatment schemes.

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  Fig. 2 Overall survival rates by treatment group.*monthly 5-FU+cisplatin †weekly cisplatin.

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  Fig. 3 Disease free survival rates by treatment group.*monthly 5-FU+cisplatin, †weekly cisplatin.

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  Fig. 4 Distant metastasis free survival rates by treatment group.*monthly 5-FU+cisplatin, †weekly cisplatin.

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