Anesth Pain Med.  2006 Oct;1(2):133-138.

Effect of Intra-cuff 4% Lidocaine on the Dosage of Nitroglycerine Required to Maintain Hemodynamic Stability before and after Extubation in Patients with Hypertension

• Jung WS
• Lee KC
• Kim HS
• Choi JJ
• Lee D

Abstract

BACKGROUND: Elevated blood pressures during emergence from general anesthesia in patients with hypertension often result in undesirable complications such as myocardial ischemia, intracranial hemorrhages. The aim of this study was to assess the effect of intracuff 4% lidocaine on the dosage of nitroglycerine required to maintain the stable blood pressure during peri-extubation period in patients with hypertension.
METHODS
Forty-nine patients scheduled for elective surgery were randomly allocated to group 1 and 2. We filled endotracheal tube's cuff with normal saline for group 1 and with 4% lidocaine for group 2. Blood pressures and heart rates were recorded before operation, during emergence, and after extubation. Nitroglycerine infusion was adjusted to maintain systolic blood pressure below 150 mmHg. Total infused dosages of nitroglycerine were recorded during operation and after stop of inhalational anesthetics for comparison of both groups' hemodynamic stability.
RESULTS
Mean infused volume (microg/kg/min) of nitroglycerine during peri-extubation period was less in the group 2 than group 1.
CONCLUSIONS
Intra-cuff 4% lidocaine in patients with hypertension during emergence from general anesthesia reduces the nitroglycerine dosage required to maintain hemodynamic stability.

Keyword

hypertension; intra-cuff; lidocaine; nitroglycerine

MeSH Terms

Anesthesia, General
Anesthetics
Blood Pressure
Heart Rate
Hemodynamics*
Humans
Hypertension*
Intracranial Hemorrhages
Lidocaine*
Myocardial Ischemia
Nitroglycerin*
Anesthetics
Lidocaine
Nitroglycerin